Inferring subnetworks from perturbed expression profiles
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- Inferring subnetworks from perturbed expression profiles D. Pe’er, A. Regev, G. Elidan, N. Friedman 2001 🛫 2023-06-26 !!2 citation reading link todoist Print:: ❌ Zotero Link:: @peerInferringSubnetworksPerturbed2001.md; Pe’er et al_2001_Inferring subnetworks from perturbed expression profiles.pdf PDF:: NA Files:: @peerInferringSubnetworksPerturbed2001.md; Pe’er et al_2001_Inferring subnetworks from perturbed expression profiles.pdf Reading Note:: Web Rip::
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Genome-wide expression profiles of genetic mutants provide a wide variety of measurements of cellular responses to perturbations. Typical analysis of such data identifies genes affected by perturbation and uses clustering to group genes of similar function. In this paper we discover a finer structure of interactions between genes, such as causality, mediation, activation, and inhibition by using a Bayesian network framework. We extend this framework to correctly handle perturbations, and to identify significant subnetworks of interacting genes. We apply this method to expression data of S. cerevisiae mutants and uncover a variety of structured metabolic, signaling and regulatory pathways. © Oxford University Press 2001.
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