A three-node Turing gene circuit forms periodic spatial patterns in bacteria
Read:: - [x] Tica et al. (2023) - A three-node Turing gene circuit forms periodic spatial patterns in bacteria ➕2024-04-15 !!2 rd citation link todoist Print:: ❌ Zotero Link:: Zotero Files:: attachment Reading Note:: Web Rip:: url:: https://www.biorxiv.org/content/10.1101/2023.10.19.563112v1
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Turing patterns1 are well-known self-organising systems that can form spots, stripes, or labyrinths. They represent a major theory of patterning in tissue organisation, due to their remarkable similarity to some natural patterns, such as skin pigmentation in zebrafish2, digit spacing3,4, and many others. The involvement of Turing patterns in biology has been debated because of their stringent fine-tuning requirements, where patterns only occur within a small subset of parameters5,6. This has complicated the engineering of a synthetic gene circuit for Turing patterns from first principles, even though natural genetic Turing networks have been successfully identified4,7. Here, we engineered a synthetic genetic reaction-diffusion system where three nodes interact according to a non-classical Turing network with improved parametric robustness6. The system was optimised in E. coli and reproducibly generated stationary, periodic, concentric stripe patterns in growing colonies. The patterns were successfully reproduced with a partial differential equation model, in a parameter regime obtained by fitting to experimental data. Our synthetic Turing system can contribute to novel nanotechnologies, such as patterned biomaterial deposition8,9, and provide insights into developmental patterning programs10.
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Uses ecoli and fits activity to parameters in a math model.
Some interesting uses but a little out of my scope
As well as some interesting information about turing pattern science and 2d automatas